Oseltamivir phosphate is an ethyl ester prodrug widely used in the treatment and prevention of both influenzavirus A and B infections. The conversion of oseltamivir to its active metabolite oseltamivir carboxylate is dependent on ester hydrolysis mediated by carboxylesterase
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چکیده
1 Activation of the antiviral prodrug oseltamivir is impaired by two newly identified carboxylesterase 1 variants Hao-Jie Zhu and John S. Markowitz Department of Pharmaceutical and Biomedical Sciences (H.J.Z., J.S.M.), Laboratory of Drug Disposition and Pharmacogenetics (H.J.Z., J.S.M.), Charles P. Darby Children’s Research Institute, Medical University of South Carolina DMD Fast Forward. Published on November 20, 2008 as doi:10.1124/dmd.108.024943
منابع مشابه
Short Communication Activation of the Antiviral Prodrug Oseltamivir Is Impaired by Two Newly Identified Carboxylesterase 1 Variants
Oseltamivir phosphate is an ethyl ester prodrug widely used in the treatment and prevention of both Influenzavirus A and B infections. The conversion of oseltamivir to its active metabolite oseltamivir carboxylate is dependent on ester hydrolysis mediated by carboxylesterase 1 (CES1). We recently identified two functional CES1 variants p.Gly143Glu and p.Asp260fs in a research subject who displa...
متن کاملActivation of the antiviral prodrug oseltamivir is impaired by two newly identified carboxylesterase 1 variants.
Oseltamivir phosphate is an ethyl ester prodrug widely used in the treatment and prevention of both Influenzavirus A and B infections. The conversion of oseltamivir to its active metabolite oseltamivir carboxylate is dependent on ester hydrolysis mediated by carboxylesterase 1 (CES1). We recently identified two functional CES1 variants p.Gly143Glu and p.Asp260fs in a research subject who displa...
متن کاملShort Communication Activation of the Antiviral Prodrug Oseltamivir Is Impaired by Two Newly Identified Carboxylesterase 1 Variants
Oseltamivir phosphate is an ethyl ester prodrug widely used in the treatment and prevention of both Influenzavirus A and B infections. The conversion of oseltamivir to its active metabolite oseltamivir carboxylate is dependent on ester hydrolysis mediated by carboxylesterase 1 (CES1). We recently identified two functional CES1 variants p.Gly143Glu and p.Asp260fs in a research subject who displa...
متن کاملAnalytical Methodologies for the Determination of Oseltamivir
Oseltamivir phosphate is an antiviral drug used in the treatment and prophylaxis of both influenza virus A and influenza virus B. Oseltamivir phosphate is an ethyl ester pro-drug that is rapidly and extensively metabolized by esterases in the gastrointestinal tract and liver to its active form, oseltamivir carboxylate. There are some analytical methods in the literature for the analysis of both...
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PURPOSE Oseltamivir is widely used in the treatment and prophylaxis of influenza A and B viral infections. It is ingested as an oral prodrug that is rapidly metabolized by carboxylesterase 1 (CES1) to its active form, oseltamivir carboxylate. Dexamethasone is also used in the treatment of acute respiratory distress syndrome, a severe complication of influenza; however, its influence on the phar...
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